Enantioselective one-pot synthesis of dihydroquinolones via BINOL-derived Lewis acid catalysis.
نویسندگان
چکیده
A high-yielding and diastereoselective route to biologically significant 2-aryl- and 2-alkyl-3-amido dihydroquinolones has been developed in up to 90 : 10 e.r. by employing a novel Lewis acidic BINOL-derived copper(ii) catalyst.
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α-Amino nitriles are synthesized in a one-pot, three-component coupling of aldehydes (or ketones), aniline, and trimethylsilyl cyanide using a catalytic amount of choline chloride.2ZnCl2 as a bio Lewis acidic ionic liquid. Mild Lewis acidic characteristic of this ionic liquid allows efficient synthesis of α-amino nitriles from acid sensitive aldehydes.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 12 28 شماره
صفحات -
تاریخ انتشار 2014